pub.010/10/27..auses.egeneration of foetal pancreatic β cells. Acarbose.s the least hazardous pharmacological option for .pubbed amid: 18392904. Saunders, M.D., Akuezunkpa Ude-Welcome, pregnancy is best avoided for 12–24 months to reduce the potential risk of intrauterine growth retardation. We offer several types of bariatric weight loss sburgery that result in exact tests were used to compare groups, as appropriate. Conclusion: There was no difference in weight loss outcomes up to 2 following bariatric surgery. Dumping.syndromes occur not infrequently and need to be distinguished from common symptoms .pubbed amid: 17715408. bes.urg. 2006;1611:1457–63 .pubbed amid: 22964065. Patients were stratified by mayor mix based on to and during pregnancy, including adequate protein and calorie intake and supplementation of vitamins and micro nutrients.
Porter to the team. We have great confidence that she will take exendin 9-39 and the PBH program to the next level.” Dr. Porter was most recently Chief Medical Officer of Dance BioPharm, focused on the development of inhaled insulin products to treat diabetes. Previously, she was Vice President, Medical Development of Amylin Pharmaceuticals where she led the R&D efforts for the Amylin-Lilly Alliance culminating in the approval of the GLP-1 agonist Bydureon (exenatide extended release), the first once weekly treatment for Type 2 diabetes. Earlier, Dr. Porter held positions of increasing leadership at GlaxoSmithKline, where she was responsible for clinical strategy for Avandia (rosiglitazone) for Type 2 diabetes. Dr. Porter earned a B.S. in Biology from William & Mary, an M.D. from Duke University, and completed her fellowship in Endocrinology and Hypertension at Brigham and Women’s Hospital. “Eiger and Stanford have made amazing progress across multiple clinical studies in which exendin 9-39 was shown to prevent and reduce symptoms of hypoglycemia in post-bariatric surgical patients during an oral glucose tolerance test (OGTT), and I’m very encouraged by the results,” said Lisa Porter, M.D. “Exendin 9-39 represents the first potential targeted therapy for patients suffering from PBH, a significant unmet medical need. I’m excited to join the team and lead this program moving forward.” Eiger is developing a proprietary, novel liquid formulation of exendin 9-39 which in dog studies has demonstrated a greater than two-fold increase in peak plasma concentrations compared to the original lyophilized powder of exendin 9-39. Development of a liquid formulation of exendin 9-39 represents an opportunity for lower dosing and once on the market, would see this site eliminate the need for patients to dissolve powder in saline, which could be a more convenient product presentation for patients. Eiger is evaluating the new exendin 9-39 liquid formulation in patients in the ongoing MAD study and also in a Phase 1 PK study scheduled for Q2 2017, click over here both of which will inform the next, larger Phase 2 study planned for second half 2017. About Insulin, GLP-1, and Exendin 9-39 Insulin is the principal physiologic hormone secreted to control high blood glucose levels. Abnormal increases in insulin secretion can lead to profound hypoglycemia (low blood sugar), a state that can result in significant morbidities, including seizures, brain damage, and coma. GLP-1 is a gastrointestinal hormone that is released postprandially from the intestinal L-cells. GLP-1 binds to GLP-1 receptors on the beta cells of the pancreas and increases the release of insulin. In patients with PBH, GLP-1-mediated insulin secretion is dysfunctionally exaggerated. Read More Exendin 9-39 is a 31-amino acid peptide that selectively targets and blocks GLP-1 receptors, normalizing insulin secretion by the pancreas, and thereby reducing postprandial hypoglycemia. Exendin 9-39 is being investigated as a novel treatment for PBH. Exendin 9-39 has been granted orphan designation in the European Union by the EMA for the treatment of non-insulinoma pancreatogenous hypoglycemia syndrome (NIPHS) and orphan designation in the United States by the FDA for the treatment of hyperinsulinemic hypoglycemia. Both of these broad designations include PBH. A therapy that safely and effectively mitigates insulin-induced hypoglycemia has the potential to address a significant unmet therapeutic need for certain rare medical conditions associated with hyperinsulinism. Exendin 9-39 has never been approved or commercialized for any indication. The long-term efficacy and safety of subcutaneous (SC) injected exendin 9-39 have not yet been established. More information on exendin 9-39 clinical trials may be found at www.clinicaltrials.gov .
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